DJ‐1, PINK1, and their effects on mitochondrial pathways
Identifieur interne : 002788 ( Main/Corpus ); précédent : 002787; suivant : 002789DJ‐1, PINK1, and their effects on mitochondrial pathways
Auteurs : Mark R. CooksonSource :
- Movement Disorders [ 0885-3185 ] ; 2010.
English descriptors
- KwdEn :
- DJ‐1, PINK1, genetics, parkin, parkinsonism.
Abstract
Genetic forms of parkinsonism are interesting for two particular reasons. First, finding a gene identifies a cause for a disease that would otherwise be unexplained. Second, finding several genes for the same disorder allows us to reconstruct molecular pathways that, in the example of Parkinson's disease, are be associated with the survival of dopamine neurons in the substantia nigra. Two rare causes of parkinsonism, DJ‐1 and PINK1, are associated with mitochondria. This organelle has long been linked with Parkinson's disease, and recent results are starting to show how mutations impact mitochondrial function. In this short review, I will discuss how we can use some of this information to understand why it is that neurons become dysfunctional in PD. © 2010 Movement Disorder Society
Url:
DOI: 10.1002/mds.22713
Links to Exploration step
ISTEX:AB427D4E84101BD7B956FEBA09627EF2870C9754Le document en format XML
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